Department of Chemistry and Biochemistry, CSUSM

Sajith Jayasinghe

Kegulian NC, Sankhagowit S, Apostolidou M, Jayasinghe SA, Malmstadt N, Butler PC, Langen R., (2015), Membrane Curvature-sensing and Curvature-inducing Activity of Islet Amyloid Polypeptide and Its Implications for Membrane Disruption. J. Biol. Chem., 290(43):25782-25793.

Ritzel, R.A., Jayasinghe, S., Hansen, J.B., Sturis, J., Langen, R., and Butler, P.C., (2010), Beta-cell selective K(ATP)-channel activation protects beta cells and human islets from human islet amyloid polypeptide induced toxicity. Regulatory Peptides, 165(2-3): 158-162.

Bedrood, S., Jayasinghe, S., Sieburth, D., Chen, M., Erbel, S., Butler, P.C., Langen, R., and Ritzel, R.A., (2009), Annexin A5 directly interacts with amyloidogenic proteins and reduces their toxicity. Biochemistry, 48(44):10568-76.

Snider, C., Jayasinghe, S.A., Hristova, K., White, S.H., (2009), Membrane Protein Explorer: A Tool for Exploring Membrane Protein Topology. Protein Science,18(12):2624-8.  

Apostolidou, M., Jayasinghe, S.A., Langen, R., (2008), Structure of -helical membrane bound IAPP and its implications for membrane-mediated misfiling.  Journal of Biological Chemistry, 283(25): 17205-17210.

Jayasinghe S.A. and Langen, R., (2007), Membrane interaction of islet amyloid polypeptide. Biochemical et. Biophysica Acta. 1768(8): 2002-2009.

Fernandez-Vidal, M., Jayasinghe, S., Ladokhin, A.S., White, S.H., (2007), Folding amphipathic helices into membranes: amphiphilicity trumps hydrophobicity. Journal of Molecular Biology, 370: 459-470.  

Meier, J.J., Kayed, R., Lin, C.Y., Gurlo, T., Haataja, L., Jayasinghe, S., Langen, R., Glabe, C.C., Butler, P.C., (2006), Inhibition of hIAPP fibril formation does not prevent beta-cell death: Evidence for distinct actions of oligomers and fibrils of hIAPP.  American Journal of Physiology - Endocrinology and Metabolism, 291(6): 1217-1324.

Jayasinghe, S.A., and Langen R., (2005).  Lipid Membranes Modulate the Structure of Islet Amyloid Polypeptide.  Biochemistry, 44: 12113-12119.

Jayasinghe, S.A., and Langen R., (2004). Identifying structural features of fibrillar islet amyloid polypeptide using site-directed spin labeling. Journal of Biological Chemistry, 279:48420-48425.

Ellena, J.F., Moulthrop J., Wu, J., Rauch, M., Jayasinghe, S., Castle, J.D., and Cafiso, D.S., (2004). Membrane position of a basic aromatic peptide that sequesters phosphatidylinositol 4,5 bisphosphate determined by site-directed spin labeling and high-resolution NMR. Biophysical Journal, 87:3221-3233.

Isas, J.M., Patel, D.R., Jao, C., Jayasinghe, S., Curtailer, J.P., Haigler, H.T., and Langen, R.(2003). Global structural changes in annexin 12- The role of phospholipids, Ca2+, and pH. Journal of Biological Chemistry, 278:30227-30234.

Jayasinghe, S., Hristova, K., and White, S.H. (2001). Transmembrane helix energetics and prediction accuracy. Journal of Molecular Biology, 312:927-934.

Jayasinghe, S., Hristova, K., and White, S.H. (2001). Metope: A database of membrane protein topology. Protein Science, 10:455-458.

White, S.H., Ladokhin, A.S., Jayasinghe, S., and Hristova, K. (2001). How membranes shape protein structure.  Journal of Biological Chemistry, 276:32395-32398.

Ladokhin, A.S., Jayasinghe, S., and White, S.H. (2000). How to measure and analyze tryptophan fluorescence in membranes properly, and why bother? Analytical Biochemistry, 285:235-245.

Hubbard, C., Singleton, D., Rauch, M., Jayasinghe, S., Cafiso, D., and Castle, D. (2000). The secretory carrier membrane protein family: Structure and membrane topology. Molecular Biology of the Cell, 11:2933-2947.

Jayasinghe, S., Barranger-Mathys, M., Ellena, J.F., Franklin, C., and Cafiso, D.S. (1998). Structural features that modulate the transmembrane migration of a hydrophobic peptide in lipid vesicles. Biophysical Journal, 74:3023-3030.

Franklin, J.C., Ellena, J.F., Jayasinghe, S., Kelsh, L.P., and Cafiso, D.S. (1994). The structure of micelle-associated alamethicin from 1H NMR. Evidence for conformational heterogeneity in a voltage-gated peptide. Biochemistry, 33:4036-4035.

PUBLICATIONS: Journal Articles